Restoring Skeletal Muscle in an Experimental Model of Chronic Obstructive Pulmonary Disease

Grant number: 628492 | Funding period: 2010 - 2014

Completed

Abstract

Most people think that the serious disabilities of COPD (emphysema) patients follows damage to their lungs but wasted muscles may be even more important. We can not regrow lung but we have found a way that might help regrow muscle. We plan to use stem cells to make one of the body's own cells called 'macrophages' and genetically engineer these cells to help deliver healing proteins directly into the muscle. Making muscle stronger will help COPD patients live longer and improve quality of life.

Related publications (3)

Serum amyloid A induces toll-like receptor 2-dependent inflammatory cytokine expression and atrophy in C2C12 skeletal muscle myotubes

SL Passey, S Bozinovski, R Vlahos, GP Anderson, MJ Hansen

2016-01-01

Background: Skeletal muscle wasting is an important comorbidity of Chronic Obstructive Pulmonary Disease (COPD) and is strongly co..

IL-17A and serum amyloid A are elevated in a cigarette smoke cessation model associated with the persistence of pigmented macrophages, neutrophils and activated NK cells

MJ Hansen, SPJ Chan, SY Langenbach, LF Dousha, JE Jones, S Yatmaz, HJ Seow, R Vlahos, GP Anderson, S Bozinovski

2014-11-18

While global success in cessation advocacy has seen smoking rates fall in many developed countries, persistent lung inflammation i..

The lung inflammation and skeletal muscle wasting induced by subchronic cigarette smoke exposure are not altered by a high-fat diet in mice

MJ Hansen, H Chen, JE Jones, SY Langenbach, R Vlahos, RC Gualano, MJ Morris, GP Anderson

2013-11-19

Obesity and cigarette smoking independently constitute major preventable causes of morbidity and mortality and obesity is known to..

University of Melbourne Researchers

Michelle Hansen

Louis Irving

Gary Anderson